StemRegenin 1 (SR1)

CAS No. 1227633-49-9

StemRegenin 1 (SR1)( SR1 )

Catalog No. M10879 CAS No. 1227633-49-9

StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 30 In Stock
10MG 47 In Stock
25MG 88 In Stock
50MG 149 In Stock
100MG 272 In Stock
200MG 418 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    StemRegenin 1 (SR1)
  • Note
    Research use only, not for human use.
  • Brief Description
    StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.
  • Description
    StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.(In Vitro):StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
  • In Vitro
    StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. Stem Regenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that Stem Regenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, Stem Regenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
  • In Vivo
    ——
  • Synonyms
    SR1
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1227633-49-9
  • Formula Weight
    429.54
  • Molecular Formula
    C24H23N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 86 mg/mL (200.21 mM)
  • SMILES
    OC1=CC=C(CCNC2=C3N=CN(C(C)C)C3=NC(C4=CSC5=CC=CC=C54)=N2)C=C1
  • Chemical Name
    4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Boitano AE, et al. Science, 2010, 329(5997), 1345-1348.
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