
StemRegenin 1 (SR1)
CAS No. 1227633-49-9
StemRegenin 1 (SR1)( SR1 )
Catalog No. M10879 CAS No. 1227633-49-9
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 30 | In Stock |
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10MG | 47 | In Stock |
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25MG | 88 | In Stock |
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50MG | 149 | In Stock |
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100MG | 272 | In Stock |
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200MG | 418 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameStemRegenin 1 (SR1)
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NoteResearch use only, not for human use.
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Brief DescriptionStemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.
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DescriptionStemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.(In Vitro):StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
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In VitroStemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. Stem Regenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that Stem Regenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, Stem Regenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
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In Vivo——
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SynonymsSR1
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PathwayEndocrinology/Hormones
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TargetAhR
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RecptorAhR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1227633-49-9
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Formula Weight429.54
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Molecular FormulaC24H23N5OS
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Purity>98% (HPLC)
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SolubilityDMSO: 86 mg/mL (200.21 mM)
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SMILESOC1=CC=C(CCNC2=C3N=CN(C(C)C)C3=NC(C4=CSC5=CC=CC=C54)=N2)C=C1
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Chemical Name4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Boitano AE, et al. Science, 2010, 329(5997), 1345-1348.
molnova catalog



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