StemRegenin 1 (SR1)

CAS No. 1227633-49-9

StemRegenin 1 (SR1)( SR1 )

Catalog No. M10879 CAS No. 1227633-49-9

StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 30 In Stock
10MG 47 In Stock
25MG 88 In Stock
50MG 149 In Stock
100MG 272 In Stock
200MG 418 In Stock
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Biological Information

  • Product Name
    StemRegenin 1 (SR1)
  • Note
    Research use only, not for human use.
  • Brief Description
    StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.
  • Description
    StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.(In Vitro):StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
  • In Vitro
    StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR). StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. Stem Regenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that Stem Regenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, Stem Regenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
  • In Vivo
    ——
  • Synonyms
    SR1
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1227633-49-9
  • Formula Weight
    429.54
  • Molecular Formula
    C24H23N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 86 mg/mL (200.21 mM)
  • SMILES
    OC1=CC=C(CCNC2=C3N=CN(C(C)C)C3=NC(C4=CSC5=CC=CC=C54)=N2)C=C1
  • Chemical Name
    4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Boitano AE, et al. Science, 2010, 329(5997), 1345-1348.
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